Name: The BEST Creamy Mushroom and Asparagus Chicken Penne Recipe
Prep time: 10 min
Cook time: 20 min
Total time: 30 min
Cuisine: Italian-Inspired
Ingredients: 12 oz penne pasta; 1 lb boneless, skinless chicken breast (cut into bite-sized pieces); 1 tablespoon olive oil; 1 tablespoon butter; 8 oz cremini or white mushrooms (sliced); 1 bunch asparagus (trimmed and cut into 2-inch pieces); 3 cloves garlic (minced); 1 cup heavy cream; 1/2 cup chicken broth; 1/2 cup grated Parmesan cheese; Salt and pepper to taste; Optional: Red pepper flakes, chopped parsley for garnish

The BEST Creamy Mushroom and Asparagus Chicken Penne Recipe

Plate of Creamy Mushroom and Asparagus Chicken Penne topped with fresh parsley.

April 26, 2025

Introduction

If you’re craving a meal that’s rich, comforting, and irresistibly creamy, you’re in for a treat. This Creamy Mushroom and Asparagus Chicken Penne is everything a cozy dinner should be: hearty, flavorful, and surprisingly simple to make. Imagine tender bites of juicy chicken, earthy mushrooms, and crisp-tender asparagus, all wrapped in a luscious Parmesan cream sauce. It’s the kind of dish that feels special enough for guests but easy enough to pull together on a busy weeknight.
Whether you’re looking to impress at a family gathering or simply want to elevate your weekday dinner game, this recipe delivers in every way. Quick to prepare, packed with layers of savory goodness, and loved by adults and kids alike, this Creamy Mushroom and Asparagus Chicken Penne is sure to become a staple in your kitchen.

Why You’ll Love This Creamy Mushroom and Asparagus Chicken Penne

Key Benefits

One of the best things about this Creamy Mushroom and Asparagus Chicken Penne is how fast and fuss-free it is. You can have a restaurant-worthy meal on the table in under 30 minutes, perfect for those nights when you want something satisfying without spending hours in the kitchen.
The flavor is out of this world — creamy, garlicky, and packed with the kind of savory notes that make you want to go back for seconds. The mushrooms bring a deep, earthy taste while the asparagus adds a fresh, slightly crisp contrast.
Plus, it’s a dish you can actually feel good about. With nutrient-rich asparagus and hearty mushrooms, you’re sneaking some wholesome vegetables into a meal that feels like pure comfort food. It’s a winning combination of speed, flavor, and nourishment.

Suitable For

This recipe fits right into just about any occasion. It’s perfect for casual family dinners where you want something delicious but approachable. It’s also a great option for romantic date nights when you want to serve something a little extra special without the stress. Hosting friends for a weekend gathering? This creamy penne will have everyone asking for seconds. No matter the crowd or the night, it’s a guaranteed hit.

Ingredients for Creamy Mushroom and Asparagus Chicken Penne

Core Ingredients

Penne Pasta: This tube-shaped pasta is perfect for catching every drop of that luxurious cream sauce.
Boneless, Skinless Chicken Breasts: Lean, tender, and quick-cooking, these are the perfect protein base.
Olive Oil and Butter: A combination of the two adds rich flavor to the sautéed ingredients.
Cremini or White Mushrooms: Earthy and meaty, mushrooms build the dish’s savory backbone.
Fresh Asparagus: Adds a beautiful pop of color and a fresh, slightly sweet flavor.
Garlic: Minced fresh garlic gives the sauce a punch of aromatic depth.
Heavy Cream: The secret to that velvety, restaurant-style sauce.
Chicken Broth: Helps lighten the cream sauce just a little while adding savory complexity.
Parmesan Cheese: Freshly grated Parmesan melts beautifully into the sauce, delivering salty, nutty richness.
Salt and Pepper: Essential for seasoning every layer.
Optional Garnishes: Red pepper flakes for a gentle kick, chopped parsley for a bright, herby finish.

Substitutions and Tips

Vegetable Swaps: Spinach makes a great stand-in for asparagus if you want a softer texture or different flavor profile.
Lighter Version: Swap out heavy cream for half-and-half if you’re looking for a lighter but still creamy sauce.
Cheese Options: If Parmesan isn’t on hand, Pecorino Romano can step in for a saltier, sharper finish.
Gluten-Free Adaptation: Choose a sturdy gluten-free penne to keep the dish gluten-free without sacrificing texture.

Best Chicken for Creamy Mushroom and Asparagus Chicken Penne

For this recipe, boneless, skinless chicken breasts are the ideal choice. They’re lean, cook quickly, and absorb the creamy sauce beautifully.
If you prefer even more flavor, boneless, skinless chicken thighs are an excellent alternative. They stay incredibly juicy and offer a slightly richer taste that pairs well with the mushrooms and asparagus.
When shopping, look for chicken that is firm, pink, and free of excess liquid in the package. For the best texture, cut your chicken into evenly sized bite-sized pieces before cooking. This ensures that every piece cooks evenly and soaks up the delicious sauce.

Kitchen Tools You’ll Need

Must-Have Tools

Large Skillet: Preferably heavy-bottomed to promote even heat distribution.
Pasta Pot: A big pot for boiling pasta with plenty of water to avoid sticking.
Stirring Spatula: Essential for mixing sauces gently without breaking the pasta.

Nice-to-Have Tools

Pasta Tongs: Makes tossing the pasta with sauce easier and less messy.
Kitchen Thermometer: Handy for checking that your chicken is cooked to a safe internal temperature of 165°F without drying it out.

How to Make Creamy Mushroom and Asparagus Chicken Penne

Step 1: Cook the Pasta

Start by bringing a large pot of salted water to a rolling boil. The salt not only seasons the pasta from within but also enhances the final flavor of the dish. Add the penne and cook according to the package directions, but aim for al dente — tender with a slight bite at the center. This ensures that the pasta holds up well when tossed with the rich, creamy sauce later on.
Once cooked, reserve a half-cup of pasta water (in case you want to thin out the sauce later) and then drain the pasta. Toss it lightly with a little olive oil to prevent sticking while you prepare the rest of the recipe.

Step 2: Cook the Chicken

Heat a tablespoon of olive oil in a large skillet over medium heat. While the oil warms up, season your bite-sized chicken pieces generously with salt and pepper. Place the chicken in the hot skillet, giving each piece a little room to brown properly.
Avoid crowding the pan — searing the chicken in batches if necessary — and resist the temptation to move the pieces around too much. Let them develop a beautiful golden crust. Cook for about 5 to 7 minutes, turning occasionally, until the chicken is cooked through. Transfer the chicken to a plate and set it aside.

Step 3: Sauté the Vegetables

In the same skillet, lower the heat slightly and add a tablespoon of butter. As the butter melts, toss in the sliced mushrooms. Stir occasionally and let them cook until they release their moisture and begin to brown, about 4 to 5 minutes.
Add the asparagus and minced garlic next, sautéing for another 3 to 4 minutes. The asparagus should turn a vibrant green and remain crisp-tender — you want it to retain some bite for a nice textural contrast in the final dish.

Step 4: Make the Creamy Sauce

Without wiping the pan clean, pour in the chicken broth and heavy cream, scraping up any flavorful browned bits stuck to the bottom. These bits are culinary gold and add incredible depth to your sauce. Stir in the freshly grated Parmesan cheese and Italian seasoning, allowing the sauce to simmer gently for 2 to 3 minutes.
The sauce should thicken slightly but remain pourable. If it thickens too much, stir in a little reserved pasta water to reach your desired consistency.

Step 5: Combine Everything

Return the cooked chicken to the pan, along with the drained pasta. Using tongs or a large spoon, toss everything together gently, making sure each piece of chicken and each pasta tube is coated in the luscious sauce. Let everything cook together for another 2 minutes, allowing the flavors to meld and the chicken to reheat fully.

Step 6: Serve and Enjoy

Plate the Creamy Mushroom and Asparagus Chicken Penne while it’s hot, garnishing with extra Parmesan and chopped parsley if desired. This dish pairs wonderfully with a side of warm garlic bread or a simple green salad. For an extra touch, a crisp white wine like Sauvignon Blanc complements the creaminess of the sauce beautifully.

Tips for Success

One of the best ways to ensure your Creamy Mushroom and Asparagus Chicken Penne turns out perfect every time is to keep an eye on your vegetables.
Overcooked asparagus can turn mushy quickly, losing its vibrant color and fresh flavor. As soon as it brightens up and becomes tender-crisp, it’s ready.
Similarly, chicken can easily dry out if cooked too long. Always aim for a golden exterior while keeping the inside juicy. A meat thermometer is a handy tool — cook chicken to an internal temperature of 165°F for perfect results.
Freshly grated Parmesan cheese is a must. Pre-shredded varieties often contain additives that prevent smooth melting, resulting in a less creamy sauce. Taking a minute to grate your own will pay off in taste and texture.
Lastly, be sure to toss the pasta with the sauce immediately. Pasta absorbs sauce best while still warm, ensuring every bite is coated in savory, creamy goodness.

How to Store Creamy Mushroom and Asparagus Chicken Penne

At Room Temperature

After serving, do not leave the pasta out for longer than two hours. Bacteria can grow quickly at room temperature, so any leftovers should be promptly transferred to an airtight container.

In the Refrigerator

Store leftover Creamy Mushroom and Asparagus Chicken Penne in a sealed container in the refrigerator for up to three days. When reheating, add a splash of milk or chicken broth to loosen the sauce and restore its creamy texture. Gently reheat over medium-low heat on the stove or in short intervals in the microwave, stirring between each burst.

Freezing Tips

Although creamy pasta dishes can sometimes separate when frozen, you can still freeze this dish successfully with a few tricks. Allow the pasta to cool completely before transferring to a freezer-safe container.
When ready to reheat, thaw overnight in the refrigerator and then reheat gently on the stove with additional cream, broth, or milk to help re-emulsify the sauce.
Frozen Creamy Mushroom and Asparagus Chicken Penne is best enjoyed within two months for optimal flavor and texture.

Frequently Asked Questions

Can I use different pasta shapes?

Absolutely. While penne is classic for soaking up the creamy sauce, you can easily swap in other pasta shapes based on what you have on hand. Fettuccine, rigatoni, or even a sturdy gluten-free pasta all work beautifully. The key is choosing a pasta shape that can hold onto that luscious sauce in every bite.

Can I make this ahead of time?

Yes, you can definitely prepare this recipe ahead. Cook the pasta slightly under al dente if you plan to reheat later, so it doesn’t become too soft. Store the chicken, sauce, and pasta separately if possible, then toss everything together when you’re ready to serve. A splash of chicken broth or cream during reheating will help bring the sauce back to life without losing that rich, silky texture.

How do I make it lighter?

If you’re looking for a lighter version, simply replace the heavy cream with half-and-half or even evaporated milk. You’ll still get that creamy, satisfying texture with fewer calories. Adding extra vegetables like spinach or peas can also lighten up the dish while boosting the nutritional value.

What can I add for more flavor?

There are plenty of ways to jazz up this already delicious pasta. Sun-dried tomatoes offer a tangy bite, while fresh baby spinach adds vibrant color and a fresh flavor. For a little heat, sprinkle in some red pepper flakes. The beauty of this dish is how customizable it is, so feel free to make it your own.

Related Recipes

If you loved this Creamy Mushroom and Asparagus Chicken Penne, you might also enjoy:

Pâtes au poulet et sauce crémeuse au Boursin – Tender chicken with a creamy herb cheese sauce.
Saumon Toscan crémeux à l’ail avec épinards et tomates séchées – Rich and flavorful seafood pasta with spinach and sun-dried tomatoes.
Lasagnes fondantes au poulet et sauce blanche crémeuse – Comforting lasagna layers with creamy chicken filling.

Conclusion

This Creamy Mushroom and Asparagus Chicken Penne is the perfect blend of comfort, flavor, and ease, making it a recipe you’ll want to keep in your regular rotation. With tender chicken, crisp vegetables, and a rich Parmesan cream sauce, every bite feels like a warm hug. Whether you are feeding family, entertaining guests, or treating yourself, this dish brings everyone to the table with smiles.
If you give it a try, be sure to leave a comment sharing your experience. Don’t forget to bookmark this recipe or share it with someone who would love a cozy, satisfying meal.